Gössinger S M
Fortschr Neurol Psychiatr. 1983 Apr;51(4):158-63. doi: 10.1055/s-2007-1002223.
The clinical findings of a female patient with a solitary diffuse invasion of a malignant melanoma into the leptomeninx are compared to the clinical findings of other cases described in literature. It is obvious that headache is the primary symptom. In the progress of the disease, the following symptoms occur: choked papilla, weakness or loss of vision and later on disturbance of consciousness. A common clinical development is hydrocephalus internus. To confirm the initial diagnosis it is necessary to identify specific pathological cells in the cerebrospinal fluid.
将一名恶性黑色素瘤孤立性弥漫侵犯软脑膜的女性患者的临床发现与文献中描述的其他病例的临床发现进行比较。显然,头痛是主要症状。在疾病进展过程中,会出现以下症状:视乳头水肿、视力减退或丧失,随后出现意识障碍。常见的临床进展是梗阻性脑积水。为确诊初始诊断,有必要在脑脊液中识别特定的病理细胞。