Civantos F, Choi Y S, Applebaum E L
Department of Otolaryngology-Head and Neck Surgery, University of Illinois College of Medicine, Chicago.
Am J Otol. 1992 Jul;13(4):369-71.
Meningeal carcinomatosis is characterized by diffuse infiltration of the leptomeninges by metastatic cancer in patients usually with a previous history of malignancy. Primary tumors are usually adenocarcinomas of the breast or lung, or malignant melanoma. Meningeal carcinomatosis can present with headache and/or a variety of cranial neuropathies. We report a case of meningeal carcinomatosis presenting as a complete, bilateral, sudden hearing loss without other cranial nerve findings--a previously unreported presentation. Our patient also exhibited an unusual primary tumor site (esophagus) and histopathology for meningeal carcinomatosis. The case was impressive for the subsequent abrupt onset of a series of cranial neuropathies and the rapid deterioration in the patient's condition.
脑膜癌病的特征是软脑膜被转移性癌症弥漫浸润,患者通常有既往恶性肿瘤病史。原发肿瘤通常为乳腺癌或肺癌腺癌,或恶性黑色素瘤。脑膜癌病可表现为头痛和/或多种颅神经病变。我们报告一例脑膜癌病,表现为双侧突然完全性听力丧失,无其他颅神经异常表现——这是一种此前未报道过的表现。我们的患者还表现出不寻常的原发肿瘤部位(食管)以及脑膜癌病的组织病理学特征。该病例令人印象深刻的是随后一系列颅神经病变突然发作以及患者病情迅速恶化。