Sánchez-Pozo A, Lupiáñez J A, Gil A, Vargas A M, Sánchez-Medina F
Horm Metab Res. 1983 Apr;15(4):171-5. doi: 10.1055/s-2007-1018661.
The time-course of liver and kidney gluconeogenesis after L-tryptophan administration has been studied. Two and half hours after injection of L-tryptophan (0.5 g/kg body wt) a 97% inhibition of hepatic gluconeogenesis in starved rats was observed. Twelve hours later, the inhibition remained 35%. Hepatic glycogen was almost completely depleted (97%) in fed rats after 5 hours. At this time there was a severe hypoglycaemia in fed and 48 h starved rats which gradually disappeared with time, the values going back to normal after 12 hours. Tryptophan treatment was associated with a significant increase in renal gluconeogenesis in fed and 48 h starved rats with a maximum at 5 h (165% and 190% respectively). When hepatic gluconeogenesis was constantly inhibited in fed rats by periodic injection (every 4 h) of L-tryptophan, renal gluconeogenic ability remained increased throughout the experiment while blood glucose concentrations did not change. These observations suggest that kidney contributes to maintain glycaemic homeostasis under these conditions of liver gluconeogenesis impairment.
研究了给予L-色氨酸后肝脏和肾脏糖异生的时间进程。注射L-色氨酸（0.5 g/kg体重）后2.5小时，观察到饥饿大鼠肝脏糖异生受到97%的抑制。12小时后，抑制率仍为35%。喂食大鼠5小时后，肝糖原几乎完全耗尽（97%）。此时，喂食和饥饿48小时的大鼠出现严重低血糖，随着时间推移逐渐消失，12小时后血糖值恢复正常。色氨酸处理使喂食和饥饿48小时的大鼠肾脏糖异生显著增加，在5小时时达到最大值（分别为165%和190%）。当通过定期注射（每4小时一次）L-色氨酸持续抑制喂食大鼠的肝脏糖异生时，整个实验过程中肾脏糖异生能力持续增加，而血糖浓度没有变化。这些观察结果表明，在肝脏糖异生受损的这些情况下，肾脏有助于维持血糖稳态。
