Parekh S R, Patel B D, Damle S R, Thanki G M, Khutti D
Hepatology. 1983 Jul-Aug;3(4):572-6. doi: 10.1002/hep.1840030416.
Alkaline phosphatase (ALP) isoenzyme composition was studied in sera and liver from patients with Indian childhood cirrhosis (ICC). A typical pattern consisting of a fast-moving anodal preliver band with slower moving diffuse liver and placental bands followed by an intestinal band was consistently observed in sera of patients in all stages of ICC and in pregnant mothers of index ICC patients. ICC liver ALP was relatively heat-stable and inhibited by L-phenylalanine and L-leucine. The isoenzyme also had similar immunological determinants to placental ALP and adult intestinal ALP isoenzymes. Total serum ALP isoenzyme and its heat-stable component progressively increased in concentration from early to advanced stages of the disease suggesting that the diseased liver in ICC is the source of the abnormal isoenzyme.
对患有印度儿童肝硬化（ICC）的患者的血清和肝脏中的碱性磷酸酶（ALP）同工酶组成进行了研究。在ICC各阶段患者的血清以及索引ICC患者的孕妇母亲中，始终观察到一种典型模式，即有一条快速移动的阳极前肝带，随后是移动较慢的弥漫性肝带和胎盘带，接着是肠带。ICC肝脏碱性磷酸酶相对耐热，且受L-苯丙氨酸和L-亮氨酸抑制。该同工酶还具有与胎盘碱性磷酸酶和成人肠碱性磷酸酶同工酶相似的免疫决定簇。从疾病早期到晚期，血清总碱性磷酸酶同工酶及其耐热成分的浓度逐渐升高，这表明ICC中患病的肝脏是异常同工酶的来源。
