均匀染色区与致瘤性。
Homogeneously staining regions and tumorigenicity.
作者信息
Gilbert F, Balaban G, Brangman D, Herrmann N, Lister A
出版信息
Int J Cancer. 1983 Jun 15;31(6):765-8. doi: 10.1002/ijc.2910310615.
PMID:6862685
Abstract
A homogeneously staining region (HSR), a chromosome abnormality associated with gene amplification, was found to increase in length coincident with an enhancement in tumorigenicity when cells from a human retinoblastoma cell line were serially passaged in athymic (nu/nu) mice.
摘要
在将人视网膜母细胞瘤细胞系的细胞在无胸腺（裸鼠，nu/nu）小鼠中连续传代时，发现与基因扩增相关的染色体异常——均匀染色区（HSR），其长度增加，同时致瘤性增强。
Zotero 插件