Lanao J M, Dominguez-Gil A, Tabernero J M, Macias J F
Int J Clin Pharmacol Ther Toxicol. 1983 Apr;21(4):197-202.
The pharmacokinetics of amikacin was studied in 18 patients with terminal renal impairment (Clcr less than 5 ml/min during the course of 4-5 h hemodialysis sessions using four different kinds of dialyzer: RP 6, RP 514, Dialix, and Ultra Flo II. All patients received a single dose of 7.5 mg amikacin/kg body wt. at the beginning of the dialysis session. The type of dialyzers influences the serum half-life, the extraction coefficient, and the percentage of dose extracted during dialysis. A linear relationship was established between the percentage of the dose extracted by dialysis and the dialysis clearance of the antibiotic.
对18例终末期肾功能损害患者（在使用四种不同透析器：RP 6、RP 514、Dialix和Ultra Flo II进行4 - 5小时血液透析期间，肌酐清除率低于5 ml/min）的阿米卡星药代动力学进行了研究。所有患者在透析开始时接受单剂量7.5 mg/kg体重的阿米卡星。透析器类型会影响血清半衰期、提取系数以及透析期间提取的剂量百分比。透析提取的剂量百分比与抗生素的透析清除率之间建立了线性关系。
