Lanao J M, Dominguez-Gil A, Tabernero J M, Molina H D
Int J Clin Pharmacol Ther Toxicol. 1982 Jun;20(6):271-5.
The disposition kinetics of amikacin were established in 12 patients with varying degrees of renal impairment (Clcr less than 70 ml/min) after i.m. administration of a dose of 7.5 mg antibiotic/kg body wt. Administered intramuscularly, amikacin follows a single-compartment open kinetic model. A decrease may be observed in the absorption and elimination processes in this kind of patient, and mathematical relationships may be established between the variation in the pharmacokinetic parameters and the creatinine clearance. The decrease observed in the elimination constant of amikacin is similar to that observed after i.v. administration of the antibiotic. A dosage regimen for administration of the antibiotic is proposed for this kind of patient on the basis of desired peak and trough serum levels obtained throughout treatment.
对12例不同程度肾功能损害（肌酐清除率低于70 ml/min）的患者，静脉注射7.5 mg抗生素/千克体重剂量的丁胺卡那霉素后，确定了其处置动力学。丁胺卡那霉素经肌肉注射后，遵循单室开放动力学模型。在这类患者中，吸收和消除过程可能会出现下降，并且可以在药代动力学参数变化与肌酐清除率之间建立数学关系。丁胺卡那霉素消除常数的下降与静脉注射该抗生素后观察到的情况相似。根据整个治疗过程中获得的预期峰浓度和谷浓度血清水平，为这类患者提出了抗生素给药方案。
