Mor R, Pitlik S, Rosenfeld J B
Isr J Med Sci. 1983 Jun;19(6):535-7.
Simultaneous administration of indomethacin and Moduretic (Merck Sharp & Dohme, USA, 5 mg of amiloride HCl, 50 mg hydrochlorothiazide) to a 78-yr-old patient resulted in severe hyperkalemia twice. When administered alone, neither drug significantly changed the normal serum potassium levels. Laboratory findings suggest an alteration of the internal balance of potassium as the main mechanism of this particular drug-induced hyperkalemia.
一名78岁患者同时服用吲哚美辛和莫得利（默克雪兰诺公司，美国，含5毫克盐酸阿米洛利和50毫克氢氯噻嗪）后，两次出现严重高钾血症。单独使用这两种药物时，均未显著改变正常血清钾水平。实验室检查结果表明，钾的内环境平衡改变是这种特定药物所致高钾血症的主要机制。
