Wan H H, Lye M D
Postgrad Med J. 1980 May;56(655):348-50. doi: 10.1136/pgmj.56.655.348.
A patient who developed significant metabolic acidosis and severe hyperkalaemia while taking Moduretic (amiloride and hydrochlorothiazide) is reported. During the period of hyperkalaemia (maximum potassium 7-6 mmol/l) the patient's whole body potassium content was normal. His acid-base balance and serum potassium returned to normal some 10 days after stopping the drug. The possible mechanism of acidosis and hyperkalaemia in this patient is discussed.
报告了1例服用莫雷西嗪（阿米洛利和氢氯噻嗪）时发生显著代谢性酸中毒和严重高钾血症的患者。在高钾血症期间（血钾最高达7.6 mmol/L），患者全身钾含量正常。停药约10天后，其酸碱平衡和血钾恢复正常。讨论了该患者发生酸中毒和高钾血症的可能机制。
