Parks N J, Keane A T
Health Phys. 1983;44 Suppl 1:103-12. doi: 10.1097/00004032-198306001-00008.
This paper examines in humans the proposition emanating from studies in beagles that initial retention of radium varies in proportion to the calcium addition rate at the time of intake. Human calcium addition rates were scaled from those in beagles, the relative calcium accretion rates in the two species at equivalent stages of skeletal growth providing the scaling factor. The variation of radium retention with age was determined by fitting a modified power function to data on the retention of radium from about 30 to 15000 days following a series of therapeutic injections of 226Ra in humans ranging in age from 18 to 63 yr. The fractional retention R at t days following a single injection of 226Ra was described by R = (1 + t/d)-0.44. The age-dependent parameter d in the retention function was found to be proportional to the calcium addition rate at the time of injection in subjects receiving less than 200 micrograms 226Ra.
本文在人体中研究了源于比格犬研究的一个观点，即摄入镭时镭的初始滞留量与钙添加率成比例变化。人体的钙添加率是根据比格犬的钙添加率按比例缩放的，在骨骼生长的等效阶段，两个物种的相对钙积累率提供了缩放因子。通过将修正的幂函数拟合到年龄在18至63岁的人群接受一系列226Ra治疗性注射后约30至15000天镭滞留数据，确定了镭滞留量随年龄的变化。单次注射226Ra后t天的分数滞留率R由R = (1 + t/d)-0.44描述。在接受少于200微克226Ra的受试者中，发现滞留函数中与年龄相关的参数d与注射时的钙添加率成比例。
