El-Khatib E, Sharplin J, Battista J
Int J Radiat Oncol Biol Phys. 1983 Jun;9(6):853-8. doi: 10.1016/0360-3016(83)90011-1.
The lungs of mice were irradiated with single X radiation doses of 5 to 14 Gy. Six weeks after irradiation, computed tomographic (CT) scans of the mice were performed at two-week intervals. Beyond 14 weeks after irradiation, the animals were scanned at 1-week intervals. The mice irradiated to 5 and 7 Gy exhibited no change in lung density, in comparison with the unirradiated lungs of control mice up to times of 48 weeks. The mice irradiated to doses of greater than 10 Gy exhibited marked increases in lung density at 15 weeks after irradiation. Increases in density followed a similar time course for these doses, but the magnitude of the density increase was dependent on the radiation dose. An interpretation of these findings in terms of radiation pneumonitis is presented, and the possibility of using CT to monitor lung density in radiotherapy patients is discussed.
用5至14 Gy的单次X射线剂量对小鼠肺部进行照射。照射后6周，每隔两周对小鼠进行计算机断层扫描（CT）。照射14周后，每隔1周对动物进行扫描。与未照射的对照小鼠肺部相比，接受5 Gy和7 Gy照射的小鼠在长达48周的时间内肺部密度没有变化。接受大于10 Gy剂量照射的小鼠在照射后15周肺部密度显著增加。这些剂量的密度增加遵循相似的时间进程，但密度增加的幅度取决于辐射剂量。本文对这些发现从放射性肺炎的角度进行了解释，并讨论了在放射治疗患者中使用CT监测肺部密度的可能性。
