脾脏集落形成单位（CFU-S）对体内低剂量率Cf-252或光子辐射的相对生物学效应（RBE）
RBE of spleen CFU-S to low dose rate Cf-252 or photon radiation in vivo.
作者信息
Maruyama Y, Nava C, Feola J, Beach J L, Hwang H N, Williams A
出版信息
Int J Radiat Oncol Biol Phys. 1983 Jul;9(7):1049-56. doi: 10.1016/0360-3016(83)90396-6.
The biological effects of low dose rate (LDR) Cf-252 radiation were compared to LDR Cs-137 photon radiation and acute 60Co radiation. The RBEn for endogenous CFU-S in vivo was 2.1 for neutron radiation at a dose rate of 9.9 cGy/hr of Cf-252 radiation. The value was consistent with previous in vitro experiments where a value of 2.1 was found. For the low doses and low dose rates studied, we tested an acute assay dose following the LDR irradiation to determine dose-effect and RBEn. Organ size shrinkage and regeneration patterns after LDR Cf-252 and Cs-137 were also studied and showed greater growth delay for Cf-252 irradiated lympho-hemopoietic tissues.
将低剂量率（LDR）的Cf-252辐射的生物学效应与LDR Cs-137光子辐射及急性60Co辐射进行了比较。对于体内内源性脾集落形成单位（CFU-S），在Cf-252辐射剂量率为9.9 cGy/小时的中子辐射下，相对生物效应（RBE）n为2.1。该值与之前体外实验中发现的2.1这一数值一致。对于所研究的低剂量和低剂量率，我们在LDR照射后测试了急性试验剂量，以确定剂量效应和RBE。还研究了LDR Cf-252和Cs-137照射后的器官大小缩小和再生模式，结果显示Cf-252照射的淋巴造血组织生长延迟更大。
Zotero 插件