微小隐孢子虫刺激的脾脏对急性60Co以及低剂量率137Cs和252Cf辐射的放射敏感性。

Radiosensitivity of C. parvum-stimulated spleen to acute 60Co and low dose rate 137Cs and 252Cf irradiation.

作者信息

Maruyama Y, Feola J M, Magura C

出版信息

Int J Radiat Biol Relat Stud Phys Chem Med. 1984 Dec;46(6):779-85. doi: 10.1080/09553008414552011.

DOI:10.1080/09553008414552011

Abstract

Stimulation of spleen growth by injection of C. parvum led to rapid organ enlargement, and acute 60Co or low dose rate (LDR) 137Cs or 252Cf irradiation reduced the maximum enlargement achieved. Irradiations were carried out 3 days after CP injection. Sigmoid dose-response curves were observed for the fraction of maximum enlargement achieved after acute 60Co. After low dose rate 137Cs or 252Cf irradiation, exponential dose-response curves of very different slope were observed. Acute and LDR gamma-radiation produced reduced effects in the stimulated and proliferating spleen compared to LDR 252Cf neutron/gamma-irradiation which had relative biological effectiveness = 4.0 versus low dose rate 137Cs.

摘要

注射微小隐孢子虫刺激脾脏生长会导致器官迅速肿大，而急性60Co或低剂量率（LDR）137Cs或252Cf照射会降低所达到的最大肿大程度。照射在注射微小隐孢子虫后3天进行。观察到急性60Co照射后所达到的最大肿大比例的S形剂量反应曲线。低剂量率137Cs或252Cf照射后，观察到斜率非常不同的指数剂量反应曲线。与相对生物效应为4.0的低剂量率252Cf中子/γ照射相比，急性和低剂量率γ辐射对受刺激和增殖的脾脏产生的影响较小，而低剂量率137Cs的相对生物效应与之相比。