Stevenson D D
J Asthma. 1983;20 Suppl 1:31-8. doi: 10.3109/02770908309078050.
To identify and characterize aspirin sensitivity, over 500 oral aspirin challenges have been performed in patients since 1970. Protocols were developed, and an aspirin desensitization process was created as an extension of the challenge protocol. Without exception, desensitization has been achieved in 66 of 66 consecutive aspirin-sensitive asthmatics. There is also cross-desensitization with nonsteroidal anti-inflammatory drugs (NSAIDs) in the limited number of patients studied. After desensitization with either aspirin or NSAIDs, an interruption of continuous therapy is followed by a reappearance of sensitivity. Patients must be cautioned about this and the possibility of a severe reaction should aspirin be reintroduced after aspirin avoidance for 2-5 days.
自1970年以来，为了识别和表征阿司匹林敏感性，已对患者进行了500多次口服阿司匹林激发试验。制定了方案，并创建了阿司匹林脱敏程序作为激发试验方案的延伸。无一例外，66例连续的阿司匹林敏感性哮喘患者中有66例实现了脱敏。在所研究的有限数量患者中，与非甾体抗炎药（NSAIDs）也存在交叉脱敏现象。用阿司匹林或NSAIDs脱敏后，连续治疗中断会导致敏感性再次出现。必须就此向患者发出警告，并且如果在停用阿司匹林2 - 5天后重新引入阿司匹林，可能会发生严重反应。
