Folayan J O
J Biochem. 1983 Apr;93(4):1211-5. doi: 10.1093/oxfordjournals.jbchem.a134247.
Poly-5-dimethylaminouridylic acid, (poly(Me2N5U)) has been synthesized by the conversion of 5-bromouridine-5'-monophosphate to 5-dimethylaminouridine-5'-monophosphate which was later made into the 5'-diphosphate and subsequently polymerized by PNPase. The polymer formed a 1:1 hybrid with poly(A) with the ability to induce the production of interferon in chick embryoes as certain doses of the hybrid protected chick embryoes against wesselsbron virus (H 10964).
聚-5-二甲基氨基尿苷酸（聚（Me2N5U））是通过将5-溴尿苷-5'-单磷酸转化为5-二甲基氨基尿苷-5'-单磷酸而合成的，后者随后制成5'-二磷酸，然后由多核苷酸磷酸化酶聚合。该聚合物与聚（A）形成1:1杂交体，在一定剂量下，该杂交体能够诱导鸡胚产生干扰素，保护鸡胚免受韦塞尔斯布伦病毒（H 10964）的侵害。
