Folayan J O
Toxicol Lett. 1982 Jun;12(1):47-52. doi: 10.1016/0378-4274(82)90197-7.
Poly(A):poly(U) (polyadenylic acid:polyuridylic acid hybrid); poly(O8A):poly(U) (poly-8-oxy-adenylic acid:polyuridylic acid hybrid); poly(A):poly(MeNH5U) (polyadenylic acid-5-methylamino uridylic acid hybrid) and poly(O8A):poly(MeNH5U) (poly-8-oxyadenylic acid:poly-5-methylamino uridylic acid hybrid) were studied in chick embryos to compare the protection offered against Semliki forest virus (the Nigerian strain) AN 49809. The modified polymers showed a higher activity index but were more toxic than the unmodified analogue.
聚(A):聚(U)(聚腺苷酸:聚尿苷酸杂交体);聚(O8A):聚(U)(聚8-氧腺苷酸:聚尿苷酸杂交体);聚(A):聚(MeNH5U)(聚腺苷酸-5-甲基氨基尿苷酸杂交体)和聚(O8A):聚(MeNH5U)(聚8-氧腺苷酸:聚5-甲基氨基尿苷酸杂交体)在鸡胚中进行了研究,以比较它们对塞姆利基森林病毒(尼日利亚株)AN 49809的保护作用。修饰后的聚合物显示出更高的活性指数,但比未修饰的类似物毒性更大。