Vignos P J, Wagner M B, Kaplan J S, Spencer G E
J Bone Joint Surg Am. 1983 Jul;65(6):719-28.
We used biochemical and clinical variables to develop a method to predict the expected duration of independent walking following surgery and bracing in patients with Duchenne muscular dystrophy. Data from the records of fifty patients were analyzed by linear and multiple regression. The most useful factors, applied in combination, in predicting the duration of walking ability after bracing were: percentage of residual muscle strength, vital capacity, creatinine coefficient, motivation of the patient at the time of bracing, and decrease in creatinine coefficient in the two years prior to bracing. This system uses readily available variables to predict the response to bracing in patients with Duchenne muscular dystrophy. Improvement in the criteria for the selection of patients for surgery and bracing is important in view of the economic cost as well as the demands on the time and energy of these children and their parents.
我们利用生化和临床变量开发了一种方法，用于预测杜氏肌营养不良症患者手术后及佩戴支具后的独立行走预期时长。通过线性回归和多元回归分析了50例患者的记录数据。在预测佩戴支具后行走能力持续时间时，联合应用的最有用因素包括：残余肌力百分比、肺活量、肌酐系数、佩戴支具时患者的积极性以及佩戴支具前两年肌酐系数的下降情况。该系统使用易于获取的变量来预测杜氏肌营养不良症患者对支具的反应。鉴于经济成本以及对这些儿童及其父母的时间和精力的要求，改进手术和支具治疗患者的选择标准非常重要。
