[The anatomical and histological investigation of the pancreas in the 19th century and till the discovery of insulin (1921). 2. The pancreas research from the discovery of islets (1869) till the discovery of pancreas-diabetes (1889) (author's transl)].

In this study is the period of the morphological exploration of the pancreas from the discovery of islets of LANGERHANS (1869) to the discovery of pancreas-diabetes through von MERING and MINKOWSKI (1889) investigated. In his thesis has PAUL LANGERHANS the islets of pancreas and the centro-acinar cells described. In the period from 1869 to 1889 has the majority of investigators the opinion that the islets are parts of the lymphatic system. In the other hand investigators have the opinion that islets are parts of pancreatic ducts or residues of the embryonic period. RENAUT (1879) makes it possible that islets are derivatives of epithelial tissues. KUHNE (1875) gives the description of vessels in the islets of Langerhans. KUHNE and LEA (1882) have found that islets are independent of acini. This hypothesis has RUDOLPH HEIDENHAIN (1875) supposed.