血清和精液中蛋白质激素浓度的评估及其与精子计数的关系。

Evaluation of proteohormon concentrations in serum and seminal fluid and its relationship with sperm count.

作者信息

Dericks-Tan J S, Bradler H, Taubert H D

出版信息

Andrologia. 1978 May-Jun;10(3):175-82. doi: 10.1111/j.1439-0272.1978.tb03013.x.

DOI:10.1111/j.1439-0272.1978.tb03013.x

Abstract

The measurement of FSH, LH, and PRL in serum and seminal fluid of 105 men attending a male infertility clinic and 21 men of proven fertility (controls) did not reveal an interrelationship between the spermatozoal count and the level of the proteo-hormones in both biological fluid except for FSH, which was significantly higher in the serum of men with low as compared to normal sperm count (p less than 0.01). FSH in seminal fluid was significantly lower (p less than 0.01), and LH-like activity significantly higher (p less than 0.01) than in serum, while there was no difference between the respective levels of PRL. These results could be confirmed in 4 patients with azoospermia due to occlusive disease, and in 1 out of 2 vasectomized men. It was demonstrated for the first time that the higher concentration of "LH" in seminal fluid as compared to serum was due to the presence of HCG-beta or a HCG-like material cross-reacting with the antiserum against LH.

摘要

对105名前往男性不育诊所就诊的男性以及21名已证实具有生育能力的男性（对照组）的血清和精液中的促卵泡激素（FSH）、促黄体生成素（LH）和催乳素（PRL）进行测量后发现，除FSH外，两种生物体液中的精子计数与蛋白激素水平之间均无相互关系。在精子计数低的男性血清中，FSH显著高于精子计数正常的男性（p<0.01）。精液中的FSH显著低于血清（p<0.01），而LH样活性显著高于血清（p<0.01），而PRL的各自水平之间没有差异。这些结果在4例因阻塞性疾病导致无精子症的患者以及2例输精管切除男性中的1例中得到了证实。首次证明，与血清相比，精液中“LH”浓度较高是由于存在人绒毛膜促性腺激素β（HCG-β）或与抗LH抗血清发生交叉反应的类似HCG的物质。