淋巴因子增强针对细胞内病原体的非氧依赖性活性。
Lymphokine enhances oxygen-independent activity against intracellular pathogens.
作者信息
Murray H W, Byrne G I, Rothermel C D, Cartelli D M
出版信息
J Exp Med. 1983 Jul 1;158(1):234-9. doi: 10.1084/jem.158.1.234.
Abstract
To determine if mechanisms other than the generation of toxic oxygen intermediates are active against intracellular pathogens, oxidatively deficient mouse L cells and monocyte-derived macrophages from patients with chronic granulomatous disease were stimulated with soluble lymphocyte products. Despite no enhancement in oxidative activity, these cells displayed effective microbistatic activity against both T. gondii and C. psittaci. These results suggest a potential role for nonoxidative mechanisms in the mononuclear phagocyte's activity against intracellular pathogens, and indicate that lymphokines can regulate both oxygen-dependent and oxygen-independent antimicrobial responses.
摘要
为了确定除了产生毒性氧中间体之外的机制是否对细胞内病原体具有活性，用可溶性淋巴细胞产物刺激氧化缺陷型小鼠L细胞和慢性肉芽肿病患者单核细胞衍生的巨噬细胞。尽管氧化活性没有增强，但这些细胞对刚地弓形虫和鹦鹉热衣原体均表现出有效的抑菌活性。这些结果表明非氧化机制在单核吞噬细胞针对细胞内病原体的活性中具有潜在作用，并表明淋巴因子可以调节依赖氧和不依赖氧的抗菌反应。
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本文引用的文献
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J Exp Med. 1980 Jul 1;152(1):85-98. doi: 10.1084/jem.152.1.85.
2
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J Exp Med. 1981 May 1;153(5):1302-15. doi: 10.1084/jem.153.5.1302.
4
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