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淋巴因子增强针对细胞内病原体的非氧依赖性活性。

Lymphokine enhances oxygen-independent activity against intracellular pathogens.

作者信息

Murray H W, Byrne G I, Rothermel C D, Cartelli D M

出版信息

J Exp Med. 1983 Jul 1;158(1):234-9. doi: 10.1084/jem.158.1.234.

DOI:10.1084/jem.158.1.234
PMID:6864162
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187079/
Abstract

To determine if mechanisms other than the generation of toxic oxygen intermediates are active against intracellular pathogens, oxidatively deficient mouse L cells and monocyte-derived macrophages from patients with chronic granulomatous disease were stimulated with soluble lymphocyte products. Despite no enhancement in oxidative activity, these cells displayed effective microbistatic activity against both T. gondii and C. psittaci. These results suggest a potential role for nonoxidative mechanisms in the mononuclear phagocyte's activity against intracellular pathogens, and indicate that lymphokines can regulate both oxygen-dependent and oxygen-independent antimicrobial responses.

摘要

为了确定除了产生毒性氧中间体之外的机制是否对细胞内病原体具有活性，用可溶性淋巴细胞产物刺激氧化缺陷型小鼠L细胞和慢性肉芽肿病患者单核细胞衍生的巨噬细胞。尽管氧化活性没有增强，但这些细胞对刚地弓形虫和鹦鹉热衣原体均表现出有效的抑菌活性。这些结果表明非氧化机制在单核吞噬细胞针对细胞内病原体的活性中具有潜在作用，并表明淋巴因子可以调节依赖氧和不依赖氧的抗菌反应。

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Lymphokine enhances oxygen-independent activity against intracellular pathogens.淋巴因子增强针对细胞内病原体的非氧依赖性活性。
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本文引用的文献

1
Macrophage microbicidal activity. Correlation between phagocytosis-associated oxidative metabolism and the killing of Candida by macrophages.巨噬细胞杀菌活性。吞噬作用相关氧化代谢与巨噬细胞对念珠菌杀伤作用之间的相关性。
J Exp Med. 1980 Jul 1;152(1):85-98. doi: 10.1084/jem.152.1.85.
2
Failure to trigger the oxidative metabolic burst by normal macrophages: possible mechanism for survival of intracellular pathogens.正常巨噬细胞未能触发氧化代谢爆发：细胞内病原体存活的可能机制。
J Exp Med. 1980 Feb 1;151(2):328-46. doi: 10.1084/jem.151.2.328.
3
Susceptibility of Leishmania to oxygen intermediates and killing by normal macrophages.利什曼原虫对氧中间产物的敏感性及被正常巨噬细胞杀伤的情况。
J Exp Med. 1981 May 1;153(5):1302-15. doi: 10.1084/jem.153.5.1302.
4
Suppression of macrophage oxidative metabolism by products of malignant and nonmalignant cells.恶性和非恶性细胞产物对巨噬细胞氧化代谢的抑制作用。
J Exp Med. 1982 Oct 1;156(4):945-61. doi: 10.1084/jem.156.4.945.
5
Lymphokines enhance the capacity of human monocytes to secret reactive oxygen intermediates.淋巴因子可增强人类单核细胞分泌活性氧中间产物的能力。
J Clin Invest. 1982 Nov;70(5):1042-8. doi: 10.1172/jci110691.
6
Role for endogenous and acquired peroxidase in the toxoplasmacidal activity of murine and human mononuclear phagocytes.内源性和获得性过氧化物酶在小鼠和人单核吞噬细胞杀弓形虫活性中的作用。
J Clin Invest. 1982 May;69(5):1099-111. doi: 10.1172/jci110545.
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Lymphokine-mediated microbistatic mechanisms restrict Chlamydia psittaci growth in macrophages.淋巴因子介导的微生物抑制机制限制了鹦鹉热衣原体在巨噬细胞中的生长。
J Immunol. 1982 Jan;128(1):469-74.
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Inhibition of Chlamydia psittaci in oxidatively active thioglycolate-elicited macrophages: distinction between lymphokine-mediated oxygen-dependent and oxygen-independent macrophage activation.氧化活性巯基乙酸盐诱导的巨噬细胞中鹦鹉热衣原体的抑制作用：淋巴因子介导的氧依赖性和非氧依赖性巨噬细胞活化之间的区别。
Infect Immun. 1983 May;40(2):464-71. doi: 10.1128/iai.40.2.464-471.1983.
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Pretreatment with phorbol myristate acetate inhibits macrophage activity against intracellular protozoa.用佛波醇肉豆蔻酸酯乙酸盐进行预处理可抑制巨噬细胞针对细胞内原生动物的活性。
J Reticuloendothel Soc. 1982 Jun;31(6):479-87.
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