Saito H, Matsuo M, Naminohira S, Sakai T, Kitagawa H, Hirata A A
J Pharmacobiodyn. 1983 Feb;6(2):141-4. doi: 10.1248/bpb1978.6.141.
Effects of N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP), the synthetic chemotactic peptide, and its analogues on blood pressure were investigated in the rabbit, rat, mouse, dog, cat and guinea pig. The administration of FMLP (5 micrograms/kg i.v.) induced the depressor effect in the rabbit but no effect was observed in the other animal species. The only peptide which showed a similar effect as FMLP was N-formyl-L-methionyl-L-methionyl-L-phenylalanine (FMMP) among the peptides relating to FMLP. Tachyphylaxis was observed in the hypotensive action induced by the two peptides.
研究了合成趋化肽N-甲酰-L-蛋氨酰-L-亮氨酰-L-苯丙氨酸（FMLP）及其类似物对兔、大鼠、小鼠、狗、猫和豚鼠血压的影响。静脉注射FMLP（5微克/千克）可使兔产生降压作用，但在其他动物物种中未观察到效果。在与FMLP相关的肽中，唯一显示出与FMLP类似作用的肽是N-甲酰-L-蛋氨酰-L-蛋氨酰-L-苯丙氨酸（FMMP）。两种肽诱导的降压作用均出现快速耐受性。
