Patrone F, Dallegri F, Sacchetti C
Res Exp Med (Berl). 1980;177(1):19-22. doi: 10.1007/BF01851628.
The in vitro effects of the peptide N-formyl-L-methionyl-L-phenylalanine on granulocytes adhesiveness and chemotaxis were investigated. N-formyl-L-methionyl-L-phenylalanine, when used at concentration chemotactically effective, increased significantly granulocyte adhesiveness. When granulocyte adhesiveness was inhibited by colchicine, the inhibition could not be reversed by subsequent treatment with N-formyl-L-methionyl-L-phenylalanine. These results suggest that microtubular system is involved in the stimulation of granulocyte adhesiveness by N-formyl-L-methionyl-L-phenylalanine.
研究了肽N-甲酰-L-蛋氨酰-L-苯丙氨酸对粒细胞黏附性和趋化性的体外作用。N-甲酰-L-蛋氨酰-L-苯丙氨酸在趋化有效浓度下使用时，显著增加了粒细胞黏附性。当秋水仙碱抑制粒细胞黏附性后，随后用N-甲酰-L-蛋氨酰-L-苯丙氨酸处理不能逆转这种抑制作用。这些结果表明，微管系统参与了N-甲酰-L-蛋氨酰-L-苯丙氨酸对粒细胞黏附性的刺激作用。
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