采用质量碎片谱法测定血清妥洛特罗浓度：与电子捕获气相色谱法比较

Determination of serum tulobuterol concentrations by mass fragmentography: comparison with an electron-capture gas chromatographic method.

作者信息

Matsumura K, Kubo O, Sakashita T, Kato H, Watanabe K, Hirobe M

出版信息

J Pharm Sci. 1983 May;72(5):570-2. doi: 10.1002/jps.2600720526.

DOI:10.1002/jps.2600720526

Abstract

A simple and sensitive method is reported for the quantitative determination of the bronchodilator tulobuterol in human serum. Tulobuterol and an internal standard were extracted from alkalinized serum with ether and then back-extracted into dilute hydrochloric acid. After alkalinization and extraction of the aqueous solution, the extract was evaporated to dryness. The residue was silylated and subjected to mass fragmentography.

摘要

报道了一种用于定量测定人血清中支气管扩张剂妥布特罗的简单且灵敏的方法。妥布特罗和内标从碱化血清中用乙醚萃取，然后反萃取到稀盐酸中。水溶液碱化并萃取后，提取物蒸发至干。残渣进行硅烷化处理并进行质量碎片分析法。