心房利钠提取物对麻醉大鼠肾血流动力学和尿排泄的影响。
The effect of a natriuretic atrial extract on renal haemodynamics and urinary excretion in anaesthetized rats.
作者信息
Borenstein H B, Cupples W A, Sonnenberg H, Veress A T
出版信息
J Physiol. 1983 Jan;334:133-40. doi: 10.1113/jphysiol.1983.sp014484.
Abstract
- An extract of cardiac atrial tissue, when injected intravenously into anaesthetized rats, caused a large and rapid increase in renal excretion of sodium chloride. 2. The renal response to atrial extract was associated with increases in total and medullary blood flow in the kidney, as measured by microsphere and albumin uptake methods, respectively. 3. The data suggest that these changes in renal haemodynamics may contribute to, but are unlikely to be the complete cause of, the natriuresis and chloriuresis following injection of atrial tissue extract.
摘要
- 将心房组织提取物静脉注射到麻醉大鼠体内时，会导致肾对氯化钠的排泄量大幅快速增加。2. 分别通过微球法和白蛋白摄取法测量发现，肾脏对心房提取物的反应与肾脏总血流量和髓质血流量的增加有关。3. 数据表明，肾脏血流动力学的这些变化可能促成注射心房组织提取物后的利钠和利氯作用，但不太可能是其全部原因。
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