Sonnenberg H, Chong C K, Veress A T
Can J Physiol Pharmacol. 1981 Dec;59(12):1278-9. doi: 10.1139/y81-200.
An extract of rat heart atria causes a saluresis in bioassay rats. When organic acid secretion in the proximal tubule was blocked by probenecid, the saluretic response to the extract was significantly reduced. Similarly, the natriuretic response to acute hypervolemia was reduced by probenecid administration. The data indicate that the atrial natriuretic factor, like the "loop" diuretic drugs, requires proximal tubular secretion for maximal renal activity. Furthermore, the factor may play a role in the renal response to acute blood volume expansion.
大鼠心房提取物可使生物测定大鼠出现利钠作用。当丙磺舒阻断近端小管中的有机酸分泌时，对该提取物的利钠反应显著降低。同样，丙磺舒给药可降低对急性血容量过多的利钠反应。这些数据表明，心房利钠因子与“袢”利尿剂一样，需要近端小管分泌才能发挥最大的肾脏活性。此外，该因子可能在肾脏对急性血容量扩张的反应中起作用。
