Hadfield J M, Stoner H B
J Trauma. 1983 Jun;23(6):518-22. doi: 10.1097/00005373-198306000-00013.
After finding changes in the biochemical response to injury in patients who had consumed ethanol (27) we have examined the effect of acute ethanol intoxication on the outcome of injury using the bilateral hindlimb ischemia model in the rat. Technical difficulties were encountered but it was possible to devise an experiment in which realistic plasma ethanol levels and a lowered redox state were present during the response to a standard 4-hr period of bilateral hind-limb ischemia. Acute intoxication had little effect on the mortality rate or survival time. Extrapolating the findings to man it would seem that if ethanol intoxication increased the dangers associated with trauma its effect would be in increased risks of airway obstruction due to vomit, etc., rather than in altered biochemical responses.
在发现饮酒患者对损伤的生化反应有变化后（27），我们使用大鼠双侧后肢缺血模型研究了急性乙醇中毒对损伤结果的影响。遇到了技术难题，但有可能设计出一项实验，在对标准的4小时双侧后肢缺血反应期间，使血浆乙醇水平达到实际水平且氧化还原状态降低。急性中毒对死亡率或存活时间影响不大。将这些发现外推至人类，似乎如果乙醇中毒增加了与创伤相关的危险，其影响将是因呕吐等导致气道阻塞的风险增加，而非生化反应改变。
