Bondi E E, Elder D E, Guerry D, Clark W H
JAMA. 1983;250(4):503-5.
Photographic analysis of the skin markings in 92 malignant melanomas (66 superficial spreading, seven nodular, 12 acral lentiginous, and seven lentigo maligna melanomas) was undertaken. Skin markings are uniformly eradicated in areas of vertical growth phase disease and sometimes in areas of regression. Not only were skin markings always preserved in areas of radical growth phase disease, but they were sometimes accentuated. For all types of melanoma, loss of skin markings is a poor diagnostic criterion because it is a late sign associated with invasion of the dermis and thus a deteriorating prognosis.
对92例恶性黑色素瘤（66例浅表扩散型、7例结节型、12例肢端雀斑样痣型和7例恶性雀斑样痣黑色素瘤）的皮肤标记进行了摄影分析。在垂直生长期疾病区域，皮肤标记会被均匀消除，有时在消退区域也会如此。不仅在根治性生长期疾病区域皮肤标记总是得以保留，而且有时还会更加明显。对于所有类型的黑色素瘤而言，皮肤标记的消失是一个欠佳的诊断标准，因为它是一个与真皮侵袭相关的晚期征象，因而预示预后恶化。
