Tanaka T, Natsume T, Shibata H, Nozawa K, Kojima S, Tsuchiya M, Ashida T, Ikeda M
Jpn Circ J. 1983 Jul;47(7):788-94. doi: 10.1253/jcj.47.788.
The circadian rhythm of blood pressure in 11 patients with primary aldosteronism (ALD) and 15 patients with unilateral renovascular hypertension (RVH) was analyzed using the cosinor method which fits a cosine function to a series of data. In ALD, both systolic (SP) and diastolic blood pressures (DP) increased in the late evening; the amplitude and acrophase of the circadian rhythm for SP were 7.3 (5.3 to 9.3, mean and 95% confidence limits) mmHg and 20:47 (19:42 to 21:52) hours, respectively, and for DP 2.6 (1.3 to 3.9) mmHg and 21:34 (19:40 to 23:28) hours, respectively. After excision of an adrenal adenoma in 6 patients, the circadian rhythm of SP and DP was abolished. In RVH, the acrophase of the circadian rhythm of SP and DP differed by about 12 hours; the amplitude and acrophase for SP were 5.7 (3.9 to 7.5) mmHg and 17:49 (16:35 to 19:02) hours, respectively, and for DP 1.5 (0.2 to 2.7) mmHg and 6:08 (2:44 to 9:31) hours, respectively. After various surgical interventions in 8 patients, the circadian rhythm of SP persisted with little change in acrophase, while that of DP disappeared. The difference in circadian rhythm suggests a difference in mechanisms of blood pressure control in ALD and RVH.
采用余弦分析法对11例原发性醛固酮增多症（ALD）患者和15例单侧肾血管性高血压（RVH）患者的血压昼夜节律进行分析，该方法是将余弦函数拟合于一系列数据。在ALD患者中，收缩压（SP）和舒张压（DP）在傍晚后期均升高；SP昼夜节律的振幅和峰值时相分别为7.3（5.3至9.3，均值及95%可信限）mmHg和20:47（19:42至21:52）时，DP的振幅和峰值时相分别为2.6（1.3至3.9）mmHg和21:34（19:40至23:28）时。6例患者切除肾上腺腺瘤后，SP和DP的昼夜节律消失。在RVH患者中，SP和DP昼夜节律的峰值时相差约12小时；SP的振幅和峰值时相分别为5.7（3.9至7.5）mmHg和17:49（16:35至19:02）时，DP的振幅和峰值时相分别为1.5（0.2至2.7）mmHg和6:08（2:44至9:31）时。8例患者接受各种手术干预后，SP的昼夜节律持续存在，峰值时相变化不大，而DP的昼夜节律消失。昼夜节律的差异提示ALD和RVH在血压控制机制上存在差异。
