Parashchenko N A
Kardiologiia. 1983 Apr;23(4):49-53.
The hemodynamic profile of essential hypertension affects renal function. Renal hemodynamics tend to deteriorate as systemic circulation changes from hyper- to hypokinetic type, mainly due to increased renal vascular resistance and reduced minute blood volume. Under hypokinetic circulation, transition to the next stage of essential hypertension takes form: renal ischemia develops during the formative stage of the disease (stage I), glomerular filtration decreases during its stabilization (stage II) in the presence of renal circulatory insufficiency. Renal hemodynamic changes due to reduced cardiac output take root and are manifested during the next stages of essential hypertension irrespective of systemic circulation variant, thus determining a new level of renal functioning.
原发性高血压的血流动力学特征会影响肾功能。随着全身循环从高动力型转变为低动力型，肾血流动力学往往会恶化，这主要是由于肾血管阻力增加和每分钟血容量减少所致。在低动力循环状态下，原发性高血压进入下一阶段：在疾病形成期（I期）会出现肾缺血，在疾病稳定期（II期），由于肾循环功能不全，肾小球滤过率会降低。由于心输出量减少导致的肾血流动力学变化会持续存在，并在原发性高血压的后续阶段表现出来，而与全身循环类型无关，从而决定了肾功能的新水平。
