Drueck C, Welch G W, Pruitt B A
Am Surg. 1978 Jul;44(7):424-7.
Eleven burn patients were studied while in septic shock and during dopamine infusion. There was only one survivor. The shock state in septic burn patients is hyperdynamic with a marked increase in cardiac index but a significant loss of systemic vascular resistance. Dopamine infusion in low doses stimulated the heart by increasing the cardiac index but caused further vasodilation and exerted little beneficial effect on blood pressure. High doses of dopamine increased the systemic vascular resistance and the blood pressure to levels which more adequately perfused the kidney. Dopamine infusion in high doses will improve the septic patient's hemodynamic status. This may permit surgical treatment of the septic process to remove the cause of the shock state.
对11名烧伤患者在感染性休克期间及多巴胺输注过程中进行了研究。仅有1名患者存活。烧伤脓毒症患者的休克状态为高动力型，心脏指数显著增加，但全身血管阻力明显降低。低剂量多巴胺输注通过增加心脏指数刺激心脏，但会导致进一步血管舒张，对血压几乎没有有益作用。高剂量多巴胺可增加全身血管阻力和血压至能更充分灌注肾脏的水平。高剂量多巴胺输注可改善脓毒症患者的血流动力学状态。这可能允许对脓毒症过程进行外科治疗以消除休克状态的病因。
