近交系小鼠DDD中的肾积水

Hydronephrosis in the inbred mouse strain DDD.

作者信息

Nakajima Y, Imamura K, Onodera T, Motoi Y, Goto N

出版信息

Lab Anim. 1983 Apr;17(2):143-7. doi: 10.1258/002367783780959538.

Abstract

The inbred mouse strain DDD was found to have an extremely high incidence of hydronephrosis (37/37 in adult males and 12/32 in adult females). The hydronephrosis was classified as open with no definite cause for obstruction. The condition was either unilateral in the right kidney or bilateral. Another feature of the hydronephrotic kidney was circulatory failure. Hydronephrosis in strain DDD mice is considered to be a useful experimental animal model with additional possible use, in investigating disturbances of renal haemodynamics and function.

摘要

近交系小鼠DDD被发现肾盂积水发病率极高（成年雄性为37/37，成年雌性为12/32）。肾盂积水被归类为开放性且无明确梗阻原因。该病症要么是右肾单侧性，要么是双侧性。肾盂积水肾脏的另一个特征是循环衰竭。DDD品系小鼠的肾盂积水被认为是一种有用的实验动物模型，在研究肾血流动力学和功能紊乱方面可能还有其他用途。