长时间间歇性足部电击应激会降低大脑中甲硫氨酸脑啡肽和亮氨酸脑啡肽的水平，同时疼痛阈值也会降低。
Prolonged intermittent footshock stress decreases Met and Leu enkephalin levels in brain with concomitant decreases in pain threshold.
作者信息
McGivern R F, Mousa S, Couri D, Berntson G G
出版信息
Life Sci. 1983 Jul 4;33(1):47-54. doi: 10.1016/0024-3205(83)90710-5.
The influence of a 21 day intermittent footshock regimen upon enkephalin levels in brain and adrenals was examined in the rat. Changes in pain sensitivity as well as analgesic and hyperthermic responsiveness to morphine (7.5 mg/kg) were also monitored. Following the stress regimen, Met and Leu enkephalin levels were decreased by 40 to 50% in brain, but were unchanged in adrenals. Post-stress pain thresholds were markedly decreased in stressed animals while the analgesic properties of morphine were enhanced. Core body temperature of stressed animals was significantly raised, but the hyperthermic response to morphine was unchanged.
研究了21天间歇性足部电击方案对大鼠脑和肾上腺中脑啡肽水平的影响。还监测了疼痛敏感性的变化以及对吗啡（7.5毫克/千克）的镇痛和体温升高反应。应激方案后，脑中的甲硫氨酸脑啡肽和亮氨酸脑啡肽水平降低了40%至50%，但肾上腺中的水平未发生变化。应激动物的应激后疼痛阈值明显降低，而吗啡的镇痛特性增强。应激动物的核心体温显著升高，但对吗啡的体温升高反应未发生变化。
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