Kowalski J, Huzarska M, Jasiński R
Department of Clinical Pharmacology, Silesian Medical Academy, Katowice, Poland.
Pol J Pharmacol Pharm. 1988 Nov-Dec;40(6):621-5.
The effect of post-shock injection of 5 mg/kg fluphenazine on stress-induced analgesia (tail immersion test) and leu-enkephalin content in discrete brain areas (radioimmunoassay) was studied in male Wistar rats. The stress-induced analgesia, which was naloxone-reversible, was attenuated and shortened by fluphenazine, the drug also antagonized the stress-induced fall in hypothalamic leu-enkephalin content. Fluphenazine alone depressed the leu-enkephalin content in the medulla oblongata, and this effect was less marked in rats subjected to footshock.
在雄性Wistar大鼠中，研究了休克后注射5mg/kg氟奋乃静对应激诱导镇痛（尾浸试验）以及离散脑区亮氨酸脑啡肽含量（放射免疫测定）的影响。应激诱导的镇痛作用可被纳洛酮逆转，而氟奋乃静使其减弱并缩短，该药物还拮抗应激诱导的下丘脑亮氨酸脑啡肽含量下降。单独使用氟奋乃静可降低延髓中亮氨酸脑啡肽的含量，在遭受电击的大鼠中这种作用不太明显。
