Sherman G F, Garbanati J A, Rosen G D, Hofmann M, Yutzey D A, Denenberg V H
Life Sci. 1983 Jul 11;33(2):189-93. doi: 10.1016/0024-3205(83)90412-5.
Female rat pups were either left undisturbed in infancy and raised in lab cages or were handled in infancy and raised in enriched environments. In adulthood, animals underwent brain surgery consisting of: 1) a right neocortical ablation, 2) a left neocortical ablation, 3) a sham operation, or 4) no surgery. After recovering, they were tested for the initial direction of movement (left or right) in the open field. Nonhandled intact females were biased to move leftward indicating an asymmetrical brain organization. The intact handled-enriched group was unbiased. The right and left lesions caused the animals to move ipsilateral to the lesion, but there was no difference in the magnitude or response in either early experience group. Thus, early experience in the female rat has a different effect then in the male, and the nature of the brain organization in the two sexes is markedly different.
雌性幼鼠在幼年时要么不被打扰，在实验室笼子里饲养，要么在幼年时接受抚摸，并在丰富的环境中饲养。成年后，动物接受脑部手术，包括：1）右侧新皮层切除，2）左侧新皮层切除，3）假手术，或4）不做手术。恢复后，对它们在旷场中的初始运动方向（向左或向右）进行测试。未接受抚摸的完整雌性倾向于向左移动，表明大脑组织不对称。完整的接受抚摸且饲养环境丰富的组没有偏向性。右侧和左侧损伤导致动物向损伤同侧移动，但在任一早期经历组中，其幅度或反应没有差异。因此，雌性大鼠的早期经历与雄性不同，两性的大脑组织性质明显不同。
