Finnström O, Lundqvist P, Mårtensson J, Sörbo B
Metabolism. 1983 Jul;32(7):732-5. doi: 10.1016/0026-0495(83)90133-6.
The excretion of sulfur-containing compounds was determined on the third and sixth day of life in male infants and the results were compared with those previously obtained on fed and fasting men. The output of total sulfur and inorganic sulfate was very low on the third day of life but had increased by the sixth day to levels found in the fasting men, whereas the excretion of mercaptolactate in the newborns decreased from the third to the sixth day of life. These results may be explained by the initial fasting state of neonates followed by an anabolic phase. Neonates excreted acid-labile ester sulfate and mercaptoacetate at levels similar to those found in adults, but the neonatal urine also contained sulfate esters (probably steroid sulfates) that required more drastic acid conditions for hydrolysis. Raised concentrations of sulfur-containing amino acids (methionine, cystathionine, cyst(e)ine and taurine) were found in neonatal urine in confirmation of earlier reports. The excretion of thiosulfate could only be determined in newborns on the sixth day and was low in comparison with that of adults. High urinary thiocyanate concentrations were found in newborns fed by tobacco-smoking mothers, whereas the excretion of thiocyanate was low in other newborns. The possible medical hazards from the exposure of neonates to thiocyanate are emphasized.
在男婴出生后的第三天和第六天测定了含硫化合物的排泄情况，并将结果与之前在进食和禁食男性身上获得的结果进行了比较。出生第三天时，总硫和无机硫酸盐的排出量非常低，但到第六天时已增加到禁食男性中的水平，而新生儿中巯基乳酸的排泄量在出生后的第三天到第六天有所下降。这些结果可以用新生儿最初的禁食状态随后进入合成代谢阶段来解释。新生儿排出的酸不稳定酯硫酸盐和巯基乙酸盐的水平与成年人相似，但新生儿尿液中还含有需要更剧烈酸性条件才能水解的硫酸酯（可能是类固醇硫酸盐）。在新生儿尿液中发现含硫氨基酸（蛋氨酸、胱硫醚、胱氨酸和牛磺酸）浓度升高，这证实了早期的报道。硫代硫酸盐的排泄量仅在出生第六天的新生儿中测定，与成年人相比很低。由吸烟母亲喂养的新生儿尿液中硫氰酸盐浓度很高，而其他新生儿中硫氰酸盐的排泄量很低。强调了新生儿接触硫氰酸盐可能带来的医学危害。
