两种不同抗甲状腺药物引起的复发性粒细胞缺乏症。
Recurrent agranulocytosis induced by two different antithyroid agents.
作者信息
Chen B, Lang R, Jutrin Y, Ravid M
出版信息
Med J Aust. 1983 Jul 9;2(1):38-9. doi: 10.5694/j.1326-5377.1983.tb142086.x.
A 45-year-old woman with thyrotoxicosis developed agranulocytosis after treatment with propylthiouracil. When the thyrotoxicosis recurred, accompanied by a severe psychotic reaction, administration of antithyroid medication was recommenced. The patient was given methimazole instead of propylthiouracil but, 10 weeks later, agranulocytosis again occurred. This is, to the best of our knowledge, the first report of a case in which agranulocytosis followed treatment with both propylthiouracil and methimazole in the same patient.
一名45岁的甲状腺毒症女性患者在接受丙硫氧嘧啶治疗后发生了粒细胞缺乏症。当甲状腺毒症复发并伴有严重的精神反应时，重新开始使用抗甲状腺药物治疗。该患者改用甲巯咪唑而非丙硫氧嘧啶，但10周后粒细胞缺乏症再次发生。据我们所知，这是同一患者先后使用丙硫氧嘧啶和甲巯咪唑治疗后均发生粒细胞缺乏症的首例报告。
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