粒细胞缺乏症与抗甲状腺药物
Agranulocytosis and antithyroid drugs.
作者信息
Rosove M H
出版信息
West J Med. 1977 May;126(5):339-43.
Abstract
Propylthiouracil and methimazole are used widely in the treatment of hyperthyroid disorders. The most important complication of the use of these drugs is depression of the neutrophilic granulocyte count. Granulocytopenia occurs in about 4 percent and agranulocytosis occurs in about 0.3 percent of treated patients. Although this depression of the granulocyte count is reversible after the drug is discontinued, serious infection frequently accompanies agranulocytosis and accounts for almost all deaths related to the drugs. It is important to be aware of the clinical features of granulocytopenic reactions due to antithyroid drugs.
摘要
丙硫氧嘧啶和甲巯咪唑广泛用于治疗甲状腺功能亢进症。使用这些药物最重要的并发症是中性粒细胞计数降低。粒细胞减少症约发生于4%的接受治疗的患者，粒细胞缺乏症约发生于0.3%的接受治疗的患者。尽管在停药后粒细胞计数降低是可逆的，但严重感染常伴随粒细胞缺乏症，并且几乎是所有与这些药物相关死亡的原因。了解抗甲状腺药物所致粒细胞减少反应的临床特征很重要。
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