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澳大利亚国家健康与医学研究委员会降低血压的非药物方法研讨会。饮酒是高血压的一个可预防病因吗?

NHMRC workshop on non-pharmacological methods of lowering blood pressure. Is alcohol use a preventable cause of hypertension?

作者信息

Mathews J D

出版信息

Med J Aust. 1983 Jul 9;2(S1):S3-6.

PMID:6865836
Abstract

There is good evidence that hypertension is more frequently observed in alcohol-users than in non-users, and that the prevalence of hypertension is proportional to the average dose of alcohol consumed. If this association is causal, the 20% to 50% of hypertension in middle-aged Australian men which is attributable to alcohol use could prove to be entirely preventable. On the other hand, if the association is largely secondary, that is, if alcohol use and hypertension share genetic and other causes in common, then intervention to reduce alcohol consumption could have little effect on the prevalence of hypertension. Further work is needed to study the mechanisms by which alcohol use may cause hypertension, to identify the genetic factors which may determine susceptibility to hypertension in alcohol-users, and to carry out controlled intervention studies to test the hypothesis that alcohol use is a reversible cause of hypertension.

摘要

有充分证据表明,饮酒者比不饮酒者更常出现高血压,且高血压患病率与平均饮酒量成正比。如果这种关联是因果关系,那么澳大利亚中年男性中20%至50%归因于饮酒的高血压可能完全可以预防。另一方面,如果这种关联很大程度上是继发性的,也就是说,如果饮酒和高血压有共同的遗传及其他病因,那么减少饮酒的干预措施对高血压患病率可能影响甚微。需要进一步开展研究,以探讨饮酒可能导致高血压的机制,确定可能决定饮酒者对高血压易感性的遗传因素,并进行对照干预研究,以检验饮酒是高血压可逆病因这一假说。

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