Messina B, Mammarella A
Minerva Med. 1983 Jul 14;74(28-29):1771-82.
Research on healthy and diseased subjects and laboratory animals have shown that Levissima oligomineral water: a) has no unpleasant or harmful subjective and/or objective side-effects even when taken at high doses for long periods. b) Encourages diuresis. Comparison with saline solution of the same osmolality showed: 1) mean increase in diuresis: 16%; 2) more rapid elimination of water; 3) significant increase in free water clearance; 4) no change in the stock of electrolytes during protracted administration. c) Influences purine exchange: 1) by increasing uric acid clearance (same comparison); 2) by reducing the hyperuricaemising effect of a rapid i.v. fructose load; 3) by opposing hyperuricaemia due to depression of mechanisms responsible for the increase of uric acid owing to enhancement of serum lactic acid after the administration of alcohol. d) Results in a characteristic change in certain coagulation parameters when compared with saline solution and tap water. It is suggested that this method be used to recognise the persistence over time of the biological activities of bottled mineral waters.
对健康受试者、患病受试者以及实验动物的研究表明，Levissima低矿化度矿泉水：a) 即使长期高剂量饮用，也不会产生令人不适或有害的主观和/或客观副作用。b) 促进利尿。与相同渗透压的盐溶液相比显示：1) 平均利尿增加：16%；2) 水分清除更快；3) 自由水清除率显著增加；4) 长期给药期间电解质储备无变化。c) 影响嘌呤交换：1) 通过增加尿酸清除率（相同比较）；2) 通过降低快速静脉注射果糖负荷引起的高尿酸血症效应；3) 通过对抗因饮酒后血清乳酸增加导致尿酸升高的机制受抑制而引起的高尿酸血症。d) 与盐溶液和自来水相比，某些凝血参数会发生特征性变化。建议使用这种方法来识别瓶装矿泉水生物活性随时间的持续性。
