Luisi M, Franchi F, Drafta D, Stroe E
Ann Endocrinol (Paris). 1978;39(2):107-15.
The dynamics of five plasma steroids were studied by CPB and RIA in twenty patients with Cushing's syndrome of differing etiologies: pituitary induced adrenal hyperplasia (10), recurrence after adrenal surgery or pituitary irradiation (4), adrenal carcinoma (4) and adrenal adenoma (2). Basal mean values of plasma steroids, showed increase of cortisol in hyperplasia and cancer groups, increase of 17-hydroxyprogesterone (17-OH-P) in recurrence and cancer groups and decrease of testosterone in male patients. In hyperplasia, the changes in 11-desoxycortisol and 17-OH-P (respectively by CPB assay and RIA after LH-20-Sephadex separation) were the reverse of those for cortisol 2 h and 24 h after metyrapone administration. Adrenalectomy determined in all but one patients, significant decrease of cortisol and in male patients, parallel gradual increase of testosterone.
通过体外循环（CPB）和放射免疫分析（RIA）对20例不同病因的库欣综合征患者的五种血浆类固醇动力学进行了研究：垂体性肾上腺增生（10例）、肾上腺手术或垂体放疗后复发（4例）、肾上腺癌（4例）和肾上腺腺瘤（2例）。血浆类固醇的基础平均值显示，增生组和癌症组的皮质醇升高，复发组和癌症组的17-羟孕酮（17-OH-P）升高，男性患者的睾酮降低。在增生组中，甲吡酮给药后2小时和24小时，11-脱氧皮质醇和17-OH-P的变化（分别通过CPB测定和LH-20-葡聚糖凝胶分离后的RIA）与皮质醇的变化相反。除1例患者外，肾上腺切除术使所有患者的皮质醇显著降低，男性患者的睾酮则平行逐渐升高。
