Bragin E O, Vasilenko G F, Durinjan R A
Central Institute of Reflexotherapy, MoscowU.S.S.R.
Pain. 1983 May;16(1):33-40. doi: 10.1016/0304-3959(83)90083-0.
The effect of the central grey matter (CG) on pain sensitivity has been investigated in rats. It has been demonstrated that baseline pain thresholds, tested by the hot plate method (HPM) after surgical operation, were significantly greater in CG-lesioned rats than in controls. Baseline tail flick latencies did not differ from those in the control group of animals. In the CG-lesioned rats, the latencies of pain responses, measured by the hot plate and tail flick tests after stress and auricular electroacupuncture, were significantly shorter than in the control group. The analgesia in the CG-lesioned rats after auricular electrostimulation was less than that after stress. Obtained data suggest: (1) significance of the CG in the regulation of baseline pain sensitivity, tested by different methods, is variable. CG mechanisms do not play a leading role in producing the tail flick response, whereas hind paw licking is mediated through CG-dependent mechanisms. (2) Antinociceptive effect of stress and acupuncture is mediated by the CG. (3) The role of the CG in analgesic mechanisms is greater in acupuncture than in stress. (4) Apart from the CG, other antinociceptive systems are involved in the mechanisms of stress-induced analgesia.
在大鼠中研究了中枢灰质（CG）对疼痛敏感性的影响。结果表明，手术操作后通过热板法（HPM）测试的基线疼痛阈值，CG损伤大鼠显著高于对照组。基线甩尾潜伏期与动物对照组无差异。在CG损伤大鼠中，应激和耳针刺激后通过热板和甩尾试验测量的疼痛反应潜伏期显著短于对照组。耳电刺激后CG损伤大鼠的镇痛作用小于应激后的镇痛作用。获得的数据表明：（1）通过不同方法测试，CG在调节基线疼痛敏感性中的意义是可变的。CG机制在产生甩尾反应中不发挥主导作用，而后爪舔舐是通过CG依赖性机制介导的。（2）应激和针刺的抗伤害感受作用是由CG介导的。（3）CG在镇痛机制中的作用在针刺中比在应激中更大。（4）除了CG，其他抗伤害感受系统也参与了应激诱导镇痛的机制。
