Goldstein D E, König P
Pediatrics. 1983 Jul;72(1):60-4.
The hypothalamic-pituitary-adrenal axis was investigated in 15 asthmatic children treated with inhaled beclomethasone dipropionate (mean 490 micrograms/day) and 11 asthmatic control subjects receiving no corticosteroid therapy. Measurements of 24-h urinary free cortisol and 17 hydroxy corticosteroids, serum cortisol, response to ACTH, and the oral metyrapone test showed no significant difference between the two groups. All the patients' results were within normal limits, and carbohydrate metabolism, as shown by blood glucose and hemoglobin A1c, was not affected by beclomethasone therapy. Thus, in the above dose, inhaled beclomethasone does not cause suppression of the hypothalamic-pituitary-adrenal axis.
对15名接受吸入丙酸倍氯米松治疗（平均每日490微克）的哮喘儿童和11名未接受皮质类固醇治疗的哮喘对照受试者的下丘脑-垂体-肾上腺轴进行了研究。24小时尿游离皮质醇和17-羟皮质类固醇、血清皮质醇、促肾上腺皮质激素反应以及口服甲吡酮试验的测量结果显示，两组之间无显著差异。所有患者的结果均在正常范围内，且血糖和糖化血红蛋白所示的碳水化合物代谢未受倍氯米松治疗影响。因此，在上述剂量下，吸入丙酸倍氯米松不会导致下丘脑-垂体-肾上腺轴受抑制。
