匹莫齐特对脑刺激奖赏作用的时间进程。
Time course of pimozide effects on brain stimulation reward.
作者信息
Atalay J, Wise R A
出版信息
Pharmacol Biochem Behav. 1983 Apr;18(4):655-8. doi: 10.1016/0091-3057(83)90297-6.
PMID:6867071
Abstract
Lever pressing for brain stimulation reward (BSR) was tested at hourly intervals following 0.5 or 1.0 mg/kg of pimozide given intraperitoneally. Response suppression was seen within one or two hours and peak effects occurred 5-8 hours after injection. Recovery approached completion within about 24 hours. Since peak brain levels of pimozide are reached quickly, the time course of peak action suggests a complex mechanism of pimozide action.
摘要
腹腔注射0.5或1.0mg/kg匹莫齐特后，每隔一小时测试一次按压杠杆以获得脑刺激奖励（BSR）的行为。在一到两小时内观察到反应抑制，注射后5-8小时出现峰值效应。恢复在约24小时内接近完成。由于匹莫齐特能迅速达到脑内峰值水平，其峰值作用的时间进程表明其作用机制复杂。
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