基于流化床制粒的标准片剂配方研究。

Study of standard tablet formulation based on fluidized-bed granulation.

作者信息

Sunada H, Hasegawa M, Makino T, Sakamoto H, Fujita K, Tanino T, Kokubo H, Kawaguchi T

机构信息

Faculty of Pharmacy, Meijo University, Nagoya, Japan.

出版信息

Drug Dev Ind Pharm. 1998 Mar;24(3):225-33. doi: 10.3109/03639049809085614.

DOI:10.3109/03639049809085614

PMID:9876579

Abstract

In this study, acetaminophen, ascorbic acid, and ethenzamide were selected as model drugs for tableting granules. Agitation and fluidized-bed granulation were carried out at three drug contents of 30, 50, and 70%. Compared with agitation granulation, granules made by fluidized-bed granulation showed superior compressibility with wide formulation allowance for drug type and amount. Fluidized-bed granulation resulted in less granule hardness and greater plastic deformability. The granules had considerable compactness and for tablets containing 70% ethenzamide, prolonged disintegration and dissolution times were noted. These are typical features of granules produced by fluidized-bed granulation.

摘要

在本研究中，选择对乙酰氨基酚、抗坏血酸和乙水杨胺作为制粒片剂的模型药物。在三种药物含量分别为30%、50%和70%的情况下进行搅拌制粒和流化床制粒。与搅拌制粒相比，流化床制粒所制得的颗粒表现出更好的可压性，对药物类型和用量具有更宽的配方允许范围。流化床制粒导致颗粒硬度较小且塑性变形能力更强。这些颗粒具有相当的紧实度，对于含有70%乙水杨胺的片剂，观察到崩解和溶解时间延长。这些是流化床制粒所产生颗粒的典型特征。