实验性表皮增殖中的经皮吸收
Percutaneous absorption in experimental epidermal proliferation.
作者信息
Solomon A E, Lowe N J
出版信息
Arch Dermatol. 1978 Jul;114(7):1029-30.
PMID:686720
Abstract
Essential fatty acid deficiency (EFAD) results in epidermal hyperproliferation with acanthosis and hyperkeratosis. The EFAD hairless mouse has been used to study the percutaneous absorption of a 0.1% solution of 4-(14)C-hydrocortisone. In vitro absorption was increased significantly through EFAD compared with normal hairless mouse skin. This is further evidence for a defective skin barrier function in epidermal hyperproliferation.
摘要
必需脂肪酸缺乏症（EFAD）会导致表皮过度增殖，并伴有棘皮症和角化过度。EFAD无毛小鼠已被用于研究4-(14)C-氢化可的松0.1%溶液的经皮吸收。与正常无毛小鼠皮肤相比，通过EFAD的体外吸收显著增加。这进一步证明了表皮过度增殖中皮肤屏障功能存在缺陷。
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