必需脂肪酸缺乏饮食对大鼠局部氢化可的松吸收的影响。

Influence of an essential fatty acid deficient diet on absorption of topical hydrocortisone in the rat.

作者信息

Lambrey B, Schalla W, Kail N, Lahmy J P, Schaefer H

机构信息

Centre International de Recherches Dermatologiques, Sophia Antipolis, Valbonne, France.

出版信息

Br J Dermatol. 1987 Nov;117(5):607-15. doi: 10.1111/j.1365-2133.1987.tb07493.x.

DOI:10.1111/j.1365-2133.1987.tb07493.x

PMID:3689679

Abstract

Using a rat dermatosis model, produced by dietary essential fatty acid deficiency (EFAD), which is characterized by histological changes and elevated transepidermal water loss, changes in skin permeability were studied using [14C]-hydrocortisone (HC). Skin, serum and urinary levels of HC were measured, and absorption and excretion of HC in EFAD rats compared with that in control rats on a normal diet. This animal model has demonstrated the importance of the functional integrity of the horny layer in skin penetration.

摘要

利用由膳食必需脂肪酸缺乏（EFAD）产生的大鼠皮肤病模型（其特征为组织学变化和经表皮水分流失增加），使用[14C] - 氢化可的松（HC）研究皮肤通透性的变化。测量了HC在皮肤、血清和尿液中的水平，并将EFAD大鼠中HC的吸收和排泄与正常饮食的对照大鼠进行比较。该动物模型已证明角质层功能完整性在皮肤渗透中的重要性。