Shekelle R B, Gale M, Ostfeld A M, Paul O
Psychosom Med. 1983 May;45(2):109-14. doi: 10.1097/00006842-198305000-00003.
Level of hostility (Ho) was assessed by a 50-item subscale of the Minnesota Multiphasic Personality Inventory at the initial examination of 1877 employed middle-aged men who were free of coronary heart disease (CHD). Ten-year incidence of major CHD events (myocardial infarction and CHD death) was lowest in the first quintile of the Ho scale's distribution, highest in the middle quintile, and intermediate in the other three quintiles. After adjustment for age, blood pressure, serum cholesterol level, cigarette smoking, and intake of ethanol, the relative odds of a major CHD event was 0.68 for men with Ho scores less than or equal to 10 points in comparison to men with higher scores. The Ho scale was positively associated with crude 20-year mortality from CHD, malignant neoplasms, and causes other than cardiovascular--renal diseases and malignant neoplasms. After adjustment for the risk factors listed above, the Ho scale had a statistically significant, positive, monotonic association with 20-year risk of death from all causes combined. A difference of 23 points on the Ho scale, i.e., the difference between the means of the first and the fifth quintiles, was associated with a 42% increase in the risk of death. These results support the previous findings of Williams et al. with respect to the Ho scale and coronary atherosclerosis, and also suggest that the Ho scale may be associated with factors having broad effects on survival.
在对1877名无冠心病（CHD）的在职中年男性进行初次检查时，通过明尼苏达多相人格调查表的一个包含50个条目的分量表评估敌意水平（Ho）。主要冠心病事件（心肌梗死和冠心病死亡）的十年发病率在Ho量表分布的第一个五分位数中最低，在中间五分位数中最高，在其他三个五分位数中处于中间水平。在对年龄、血压、血清胆固醇水平、吸烟和乙醇摄入量进行调整后，与得分较高的男性相比，Ho得分小于或等于10分的男性发生主要冠心病事件的相对比值为0.68。Ho量表与冠心病、恶性肿瘤以及心血管 - 肾脏疾病和恶性肿瘤以外原因导致的粗20年死亡率呈正相关。在对上述危险因素进行调整后，Ho量表与所有原因合并导致的20年死亡风险存在统计学上显著的正单调关联。Ho量表上23分的差异，即第一个和第五个五分位数均值之间的差异，与死亡风险增加42%相关。这些结果支持了Williams等人先前关于Ho量表和冠状动脉粥样硬化的研究发现，也表明Ho量表可能与对生存有广泛影响的因素有关。
