溴磺酞在兔体内的胆汁排泄
Biliary excretion of bromosulfthalein in rabbit.
作者信息
Hidalgo F, González J, López M A, Esteller A
出版信息
Rev Esp Fisiol. 1983 Mar;39(1):61-7.
PMID:6867443
Abstract
The effect of bromosulfthalein (BSP) infusions at different doses on bile secretion was investigated in anaesthetized rabbits. The patterns of biliary excretion were found to be similar to other mammals, maximal biliary excretion being achieved by an infusion of 0.50 mg X kg-1 body weight X min-1. Bromosulfthalein administered at low doses under the maximum hepatic transport capacity resulted in a clear increase of bile flow which was mainly due to an osmotic mechanism. Supramaximal doses produced no effect on bile flow.
摘要
在麻醉兔中研究了不同剂量的磺溴酞钠（BSP）输注对胆汁分泌的影响。发现胆汁排泄模式与其他哺乳动物相似，通过以0.50毫克/千克体重/分钟的速率输注可实现最大胆汁排泄。在最大肝转运能力以下给予低剂量的磺溴酞钠导致胆汁流量明显增加，这主要是由于渗透机制。超最大剂量对胆汁流量没有影响。
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