通过抑制纤维蛋白溶解减少胃出血——大鼠实验研究

Reduction of gastric haemorrhage by fibrinolysis inhibition - an experimental study in rats.

作者信息

Stenberg B, Karlsson L, Alpsten M, Risberg B

出版信息

Thromb Haemost. 1983 Apr 28;49(2):106-8.

Abstract

Gastric ulcerations were induced in rats by pyloric ligature and instillation of 1.0 N HCl. After four hours all rats had developed ulcerations. Increased release of plasminogen activators from the mucosa during these conditions has previously been demonstrated. In the present study we investigated the role of fibrinolysis inhibition versus H2-receptor blockade on the gastric bleeding. Tranexamic acid - a synthetic inhibitor of the fibrinolytic system - was found to significantly (p less than 0.01) reduce blood loss into the gastric juice by 30% measured by 51Cr labelled red blood cells; cimetidine did not reduce the gastric haemorrhage under the experimental conditions used. Both treatment regimes significantly (p less than 0.02) reduced the secretion of gastric juice. These results indicate a contribution of the fibrinolytic system in gastric bleeding from experimentally induced gastric ulcerations.

摘要

通过幽门结扎和注入1.0N盐酸在大鼠中诱发胃溃疡。四小时后，所有大鼠均出现溃疡。先前已证明在这些情况下，黏膜中纤溶酶原激活剂的释放增加。在本研究中，我们研究了纤维蛋白溶解抑制与H2受体阻断对胃出血的作用。氨甲环酸——一种纤维蛋白溶解系统的合成抑制剂——被发现可显著（p<0.01）减少用51Cr标记红细胞测量的进入胃液的失血量30%；在所用的实验条件下，西咪替丁并未减少胃出血。两种治疗方案均显著（p<0.02）减少了胃液分泌。这些结果表明纤维蛋白溶解系统在实验性诱发胃溃疡引起的胃出血中起作用。