氨甲环酸与大鼠胃纤维蛋白溶解作用
Tranexamic acid and gastric fibrinolysis in the rat.
作者信息
Stenberg B, Risberg B, Peterson H I
出版信息
Thromb Haemost. 1980 Feb 29;42(5):1425-8.
An optimal inhibition of tissue fibrinolysis, studied by a histochemical fibrin slide technique in the rat stomach, was obtained by administration of tranexamic acid in a dose of 60 mg/100 g body weight. A significant fibrinolysis inhibition was found within 5 min, when tranexamic acid in this dose was given either intravenously or intragastrically. A prolonged duration of fibrinolysis inhibition was observed after intragastric administration. After 4 hr no inhibitory effect of tranexamic acid could be recorded, irrespective of the route of administration.
通过组织化学纤维蛋白玻片技术在大鼠胃中研究发现，给予剂量为60mg/100g体重的氨甲环酸可实现对组织纤维蛋白溶解的最佳抑制。静脉注射或胃内给予该剂量的氨甲环酸后，5分钟内即可发现显著的纤维蛋白溶解抑制作用。胃内给药后观察到纤维蛋白溶解抑制作用持续时间延长。4小时后，无论给药途径如何，均未记录到氨甲环酸的抑制作用。
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